Risk-Taking Propensity as a Predictor of Induction Onto Naltrexone Treatment for Opioid Dependence
نویسندگان
چکیده
منابع مشابه
Pharmacological enhancement of naltrexone treatment for opioid dependence: a review
PURPOSE: Opioid dependence (OD) is a serious and growing clinical condition with increasing social costs that requires expanding treatment beyond opioid agonist substitution. The opioid antagonist naltrexone has displayed a remarkable association of theoretical effectiveness and poor clinical utility in treating OD due to noncompliant behavior and low acceptability among patients, only partly m...
متن کاملInjectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial.
CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence. OBJECTIVE To evaluate the safety and efficacy of a sustained-release depot formulation of naltrexone in treating opioid dependence. DESIGN AND SETTING Randomized, double-blind, placebo-c...
متن کاملA systematic review and meta-analysis of naltrexone implants for the treatment of opioid dependence.
INTRODUCTION AND AIMS Naltrexone implants are used to treat opioid dependence, but their safety and efficacy remain poorly understood. We systematically reviewed the literature to assess the safety and efficacy of naltrexone implants for treating opioid dependence. DESIGN AND METHODS Studies were eligible if they compared naltrexone implants with another intervention or placebo. Examined outc...
متن کاملEfficacy of maintenance treatment with naltrexone for opioid dependence: a meta-analytical review.
AIMS To determine the efficacy of naltrexone in reducing illicit opioid use and the potential moderating role of treatment retention. DESIGN First, randomized controlled trials (RCTs) comparing the regimens of treatment using the opioid antagonist, naltrexone, with controls were analysed by meta-analysis for treatment effect with regard to a range of outcome criteria. The degree of heterogene...
متن کاملOpioid detoxification and naltrexone induction strategies: recommendations for clinical practice.
BACKGROUND Opioid dependence is a significant public health problem associated with high risk for relapse if treatment is not ongoing. While maintenance on opioid agonists (i.e., methadone, buprenorphine) often produces favorable outcomes, detoxification followed by treatment with the μ-opioid receptor antagonist naltrexone may offer a potentially useful alternative to agonist maintenance for s...
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ژورنال
عنوان ژورنال: The Journal of Clinical Psychiatry
سال: 2012
ISSN: 0160-6689
DOI: 10.4088/jcp.09m05807